Scientists from the Institute of Medical Research and Sanford-Burnham in California said they found an association between these anti-inflammatory drugs, such as aspirin, and the low number of cases occurring some types of cancer among people who regularly take these medications. This helped us to conclude that some drugs designed to combat pain and temperature, also have the ability to induce apoptosis - the death cancer cells .
The study is published in the journal Cancer Cell. In particular, experts traced effect on cancer cells medicine Sulindac . It turned out that it affects RXR (retinoic acid receptor) - a protein which conveys signals to the cell nucleus, causing genes are switched on or off.
"Nuclear receptors are excellent targets for drug development, - says senior study author Xiao-kun Zhang. - 30% of existing drugs on the market are aimed precisely at the core receptors, although the mechanism of action is not always fully understood."
Typically, RXR inhibits the growth of tumors, but in many types of malignant cancer cells produce a truncated form of their nuclear receptors that leads to the opposite effect.
According to the researchers, their study showed that the truncated RXR promote tumor growth by stimulating other proteins that help cancer cells survive. but Sulindac RXR can withstand, causing apoptosis.
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