Austrian experts discovered why some people with excess weight are generally healthy, while at the while in others the development of obesity is associated with the simultaneous development of a number of diseases. Researchers in Vienna have found a molecular key to development metabolic syndrome, in which overweight correlated with diseases - it was an enzyme produced by the liver and adipose tissue.
Medical staff University of Vienna have shown that the development of the metabolic syndrome Activity of the enzyme heme oxygenase required 1. The contents of this molecule the body can play a role of a marker, whereby it will be possible divided metabolically healthy obese people and people with obesity It should lead to the development of metabolic disorders and type 2 diabetes.
Doctors have long been engaged in the search for such biomarkers. The fact that people with excess quarter No changes in body weight of metabolism, metabolic characteristic syndrome, insulin resistance is present and there is no evidence of systemic inflammation, that is, they present "metabolically healthy 'obesity.
At the same time, scientists We noticed that subjects with metabolic disorders had a greater girth waist, abdominal obesity more pronounced, the higher the ratio triglycerides to high density lipoproteins and higher number of other molecules in the blood. His is the most successful "finding" experts say that they were able to tell the difference between "healthy" and "sick" on obesity the molecular level. After analyzing samples of blood serum and liver biopsy and adipose tissue, doctors have found that there is a direct correlation between the degree of metabolic disorders, and the levels of production of the enzyme heme oxygenase-1 in adipose tissue and liver.
Additionally it was done Several experiments on animals. They have shown that the presence in mice gene, forcing their body to produce heme oxygenase-1, affected manifestations of the metabolic syndrome. (READ MORE)
Medical staff University of Vienna have shown that the development of the metabolic syndrome Activity of the enzyme heme oxygenase required 1. The contents of this molecule the body can play a role of a marker, whereby it will be possible divided metabolically healthy obese people and people with obesity It should lead to the development of metabolic disorders and type 2 diabetes.
Doctors have long been engaged in the search for such biomarkers. The fact that people with excess quarter No changes in body weight of metabolism, metabolic characteristic syndrome, insulin resistance is present and there is no evidence of systemic inflammation, that is, they present "metabolically healthy 'obesity.
At the same time, scientists We noticed that subjects with metabolic disorders had a greater girth waist, abdominal obesity more pronounced, the higher the ratio triglycerides to high density lipoproteins and higher number of other molecules in the blood. His is the most successful "finding" experts say that they were able to tell the difference between "healthy" and "sick" on obesity the molecular level. After analyzing samples of blood serum and liver biopsy and adipose tissue, doctors have found that there is a direct correlation between the degree of metabolic disorders, and the levels of production of the enzyme heme oxygenase-1 in adipose tissue and liver.
Additionally it was done Several experiments on animals. They have shown that the presence in mice gene, forcing their body to produce heme oxygenase-1, affected manifestations of the metabolic syndrome. (READ MORE)
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