Experts from the University of California in San Francisco, within two months of laboratory rats supplied unlimited alcohol or sugar. Then, the "temptations" were excluded from the diet of the animals, which caused them during withdrawal . Rats that were sitting on the alcohol, was recorded electrical activity in the part of the brain called the nucleus accumbens (NAcb, nucleus accumbens), which plays an important role in the motivation and behavior of the target.
The increase in brain activity in the area after NAcb withdrawal the result of suppression of calcium-activated potassium channels (SK). In further studies we found out that the activation of the drug leads to suppression of SK NAcb-activity in rats experiencing withdrawal symptoms, significantly reducing their t YSU habits .Prichem Have hooked on sugar rats same effect was not observed.
These data suggest that increased activity in NAcb plays a key role in relapse of alcoholism people tied to alcohol, according to scientists. "Our study is particularly relevant because the sale has already medicine chlorzoxazone Which 30 years is used as a muscle relaxant that is capable of activating SK-channels - said study author Dr. Antonello Bonci. - Though this medication may be a lot of unexpected side effects, because it is not the purpose of reduction in craving for alcohol, it promises great potential in the fight against this addiction. It is necessary to conduct a detailed clinical studies. "
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