"One of the most interesting features of this newly discovered signaling pathway is that it differs from the signal path caused by insulin. This means that the signal path in the brown fat is likely to be activated even in patients with type 2 diabetes, where there are violations of insulin signaling, "- says senior study author Tore Bengtsson (Tore Bengtsson) from Stockholm University.
Scientists have discovered a new signaling pathway that stimulates glucose uptake in brown fat cells. They believe that this will help in the treatment of diabetes and obesity.
The findings are published in the Journal of Cell Biology.
At low temperatures, the system activates the sympathetic adrenergic receptors on the surface of brown adipose tissue, to stimulate the uptake of glucose in the blood. Then brown fat adipocytes using glucose as the source of energy to maintain body heat. Glucose uptake may also be caused by insulin.
Swiss researchers argue that mTORC2 signaling pathway is a key regulator of adrenergic receptors to stimulate glucose uptake in brown adipose tissue. The path that includes a protein kinase called MPM stimulates glucose transport and import GLUT1 protein to the surface of brown fat cells.
Apart from the fact that stimulating mTORC2 way is an effective tool for the control of blood sugar levels in patients with type 2 diabetes, these data suggest that the energy reserves of brown fat can be effective as a treatment for weight reduction.
More scientific article:
Olsen, J.M et al. Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation. J. Cell Biol., 2014, DOI: 10.1083 / jcb.201403080
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